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In Pittsburgh, mid-twentysomething Catholic schoolteacher Faith Corvatch has always believed in destiny: Based on a couple of paranormal incidents when she was a teenager, she believed she was destined to end up with a man named Damon Bradley, which is just a name, not an actual person she knows. However, she has accepted the marriage proposal of her staid podiatrist boyfriend Dwayne. Ten days before the wedding, Faith takes a telephone call for Dwayne from one of his old friends whom he hasn't seen since school days: Damon Bradley. With five days before her next class, Faith decides to follow her destiny by tracking down Damon Bradley based only on what information she has on hand, namely that he is flying to Venice, and the name of the hotel he will be staying at there. With her sister-in-law Kate, who is feeling unappreciated by her husband, Faith's brother Larry, in tow, Faith hops on a plane to Venice, planning to be back in Pittsburgh in time for her next class and for the wedding. Faith and Kate get into one close encounter after another with the phantom Damon Bradley without ever seeing him as they track him through Italy. When Faith finally meets Damon, a Boston shoe salesman in Italy on a business trip, it is love at first sight on both sides. But there is one vital piece of information about Damon concerning Faith's belief in her destiny which she must overcome if there's to be a happy ending for the pair as opposed to a life of settling for Dwayne. Meanwhile, Kate is wooed by a suave Italian, a shop owner named Giovanni.